13 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
#Dosing #Oral # ... Anticoagulation #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology ... #Hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
NOAC / DOAC Pharmacology ... Anti-Coagulants • Rivaroxaban ... • Apixaban ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
: Apixaban (25% ... Anticoagulation #Hematology ... #Pharmacology # ... Apixaban #Rivaroxaban ... Dabigatran #Edoxaban #NOAC
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
(Praxbind) - Apixaban ... Edoxaban (Lixiana), Rivaroxaban ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
Oral Xa inhibitors ... patients with VTE ... for VTE tx and ... #Rivaroxaban #Dosing ... #Pharmacology
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
VKA, Dabigatran, Rivaroxaban ... , Apixaban, Edoxaban ... , Betrixaban, DOAC ... anticoagulation #Switching #hematology ... #pharmacology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
Antidotes: • Apixaban ... #Reversal #NOAC ... #Oral #anticoagulant ... #hematology #management ... #pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
, edoxaban and rivaroxaban ... direct-acting oral ... for appropriate dosing ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
the mainstay of VTE ... - Rivaroxaban ... #Pharmacology #Pathophysiology ... #Dabigatran #Apixaban ... #NOAC #Mechanism
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
Edoxaban, rivaroxaban ... , and apixaban are ... Rivaroxaban and ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology