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doac hematology anticoagulation management anticoagulant oncology vte algorithm apixaban cancer malignancy reversal rivaroxaban anticoagulants aptt bridging cheatsheet chemotherapy cyp3a4 direct
Oral anticoagulant dosing and bridging for VTE - Dr. Joseph Shatzel @Clotmaster #VTE #DOAC #Bridging #Dosing #Oral
Clotmaster #VTE #DOAC ... Anticoagulation #Dabigatran ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology ... #Hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet Novel (or Direct) Oral Anti-Coagulants • Rivaroxaban • Apixaban
NOAC / DOAC Pharmacology ... Novel (or Direct) Oral ... • Apixaban • Dabigatran ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing Renal Dosing: Apixaban (25% renal clearance):
patients 5mg bid Dabigatran ... if CrCl < 50) Edoxaban ... Anticoagulation #Hematology ... #Pharmacology # ... #Edoxaban #NOAC
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Protamine sulfate - Dabigatran ... Betrixaban (Bevyxxa), Edoxaban ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
Switching Between Anticoagulants and DOACs VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant DOI: 10.1161/JAHA.120.017559 #Anticoagulants #DOACs #anticoagulation
and DOACs VKA, Dabigatran ... Rivaroxaban, Apixaban, Edoxaban ... , Betrixaban, DOAC ... anticoagulation #Switching #hematology ... #pharmacology
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
: • Apixaban, Edoxaban ... modified factor Xa • Dabigatran ... #Oral #anticoagulant ... #hematology #management ... #pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis. Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral ... for appropriate dosing ... direct-acting oral ... Anticoagulation #Management #Hematology
►
 Effect of Direct Oral Anticoagulants on Hemostatic Tests Horizontal bars correspond to the approximate range of detectability
Effect of Direct Oral ... concentrations of dabigatran ... , apixaban and edoxaban ... #noac #anticoagulation ... #hematology #laboratory
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
Edoxaban, rivaroxaban ... pathway whereas edoxaban ... Dabigatran has moderate ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Perioperative Management of DOACs Problem: ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
direct acting oral ... clearance (calculated using ... of Therapy • Dabigatran ... ) • Apixaban, Edoxaban ... Management #Treatment #pharmacology
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