11 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Clotmaster #VTE #DOAC ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology ... #Hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
NOAC / DOAC Pharmacology ... Novel (or Direct) Oral ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology ... management #Direct #Oral
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
if CrCl < 50) Edoxaban ... Anticoagulation #Hematology ... #Pharmacology # ... Rivaroxaban #Dabigatran #Edoxaban ... #NOAC
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Betrixaban (Bevyxxa), Edoxaban ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
: • Apixaban, Edoxaban ... #Reversal #NOAC ... #Oral #anticoagulant ... #hematology #management ... #pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral ... for appropriate dosing ... direct-acting oral ... Anticoagulation #Management #Hematology
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
Rivaroxaban, Apixaban, Edoxaban ... , Betrixaban, DOAC ... anticoagulation #Switching #hematology ... #pharmacology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... Edoxaban, rivaroxaban ... pathway whereas edoxaban ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
**Edoxaban is initiated ... bleeding risk during ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
Effect of Direct Oral ... , apixaban and edoxaban ... thrombin time #doac ... #noac #anticoagulation ... #hematology #laboratory