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dermatology rheumatology differential oncology syndrome antimda5 antimda5dm antinxp2 antinxp2dm clinical cutaneous erythematosus lupus management manifestations myelodysplastic myopathy myositis neurology pathophysiology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
polymorphism • Satellite ... Autoimmune manifestations ... (dermatomyositis ... leukocytoclastic vasculitis ... #differential #diagnosis
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
processes occur in the skin ... -> Heliotrope Rash ... #PM #Diagnosis ... Pathophysiology #Signs ... #Symptoms #Vasculitis
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
(blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... ulcerations • Skin ... #dermatology #diagnosis
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... polyneuropathy: DM ... Lack of UMN/LMN signs ... necrotizing myopathy • Autoimmune ... Muscle Biopsy: Dermatomyositis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... Episcleritis Signs ... multiforme - Dermatomyositis ... Leukocytoclastic vasculitis
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
DM with generalized ... to have typical DM ... (blue-purple) rash ... • Erythematous rash ... chest (in a V-sign
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... Still disease, dermatomyositis ... disease • Non-autoimmune ... deficiencies • Autoimmune
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... Symptoms: • Gottron rash ... papules and Gottron sign ... ) • Shawl sign ... elevated < PM and DM
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