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diagnosis differential symptoms systemic table vasculitis classification cold erythematosus inflammatory lupus myopathies myopathy scleroderma sclerosis sle ssc testing vasculitides workup
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Autoimmune diseases ... trigger - Direct skin ... 50% of patients Skin ... #diagnosis #rheumatology ... #comparison #table
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune ... thickening Signs ... acro-osteolysis, myositis ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Vasculitis, Purpura, Urticaria ... Glomerulonephritis Myositis ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... Myositis • Onset ... differential #diagnosis #comparison ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Hypocomplementemic Urticarial ... Vasculitis): - Urticaria ... Conjunctivitis, mucositis ... purpura: strong sign ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... Conjunctivitis, mucositis ... Hypocomplementemia: Urticarial ... Hypocomplementemic Urticarial ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... ) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... #rheumatology #
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