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diagnosis comparison differential antibodies associations autoantibodies cold dermatology diseases inflammatory myopathies myopathy myositis sclerosis ssc symptoms systemic testing urticaria workup
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis (Scleroderma ... Multi-system autoimmune ... thickening Signs ... #SSc #rheumatology ... #diagnosis #signs
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... Anti-Scl-70 - Scleroderma ... diseases #diagnosis #table ... #rheumatology #
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
Scleroderma Like ... reduced incidence Scleredema ... large numbers of stellate ... Diagnosis #comparison #table ... #dermatology
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
Autoimmune diseases ... trigger - Direct skin ... 50% of patients Skin ... Urticaria #diagnosis #rheumatology ... #comparison #table
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... diagnosis #comparison #rheumatology ... #table
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... ) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology
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