7 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
(Scleroderma) ... Multi-system autoimmune ... thickening Signs ... #SSc #rheumatology ... #diagnosis #signs
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Autoimmune diseases ... trigger - Direct skin ... 50% of patients Skin ... #diagnosis #rheumatology ... #comparison #table
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Sjögrens (15%) Skin ... Vasculitis, Purpura, Urticaria ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Scleroderma Like Conditions - Differential Diagnosis
Eosinophilic Fasciitis:
 - Orange peel induration (peau d'orange) of proximal extremities
Scleroderma Like ... treatment Nephrogenic Systemic ... large numbers of stellate ... Diagnosis #comparison #table ... #dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Hypocomplementemic Urticarial ... Vasculitis): - Urticaria ... purpura: strong sign ... cryoglobulinemia, urticarial ... differential #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... Hypocomplementemia: Urticarial ... Hypocomplementemic Urticarial ... maculopapular lesions, urticaria ... Differential #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
) • Anti-Mi2 (skin ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system ... Myositis #Myopathy #rheumatology