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symptoms systemic differential management sclerosis vasculitis ana anca antibodies antibody antineutrophil antinuclear antinxp2 antinxp2dm classification crisis dermatology dermatomyositis diseases lupus
Systemic Sclerosis (Scleroderma) Limited - CREST: • Calcinosis • Raynaud phenomenon • Esophageal dysmotility • Sclerodactyly •
Systemic Sclerosis (Scleroderma ... 10% - 15% • Scleroderma ... renal crisis ... #diagnosis #signs ... #symptoms #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
skin thickening Signs ... arterial HTN) • Renal ... : scleroderma renal ... #SSc #rheumatology ... #diagnosis #signs
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Systemic lupus erythematosus ... Systemic sclerosis (scleroderma ... polyangiitis without renal ... ANCA+ 30-60% • Renal-limited ... #rheumatology #
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Abdominal pain (20%) Renal ... SLE #systemic #erythematosus ... #signs #symptoms ... #diagnosis #rheumatology
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Scleroderma Renal ... Renal Crisis: ... Monitoring • Renal ... #Renal #Crisis ... #rheumatology #nephrology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... purpura: strong sign ... Vessels: Supply gut ... • Urinalysis (Renal ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... purpura: Strong sign ... ischemia • Skin: Erythematous ... purpura, joint & gut ... #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
with edema • Erythematous ... chest (in a V-sign ... shoulders (in a shawl sign ... • Clear cell renal ... #management #rheumatology
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