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differential management cancer causes classification diuresis diuretics excretion gitelman injury kidney leukostasis lysis medications oncology pharmacology table tls tumor
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Cancer Related • Hypercalcemia ... gammopathy of renal ... malignancies Treatment ... #Differential #Diagnosis ... Classification #Nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Family history of hypokalemia ... • Unexplained hypokalemia ... pressure Labs: • Hypokalemia ... #diagnosis #nephrology ... #Hypokalemia
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... Transcellular Shifts: - Alkalosis ... plasma insulin (treatment ... or induced) #Hypokalemia ... #nephrology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
fever - ACS, AKI ... , acute limb ischemia ... , Elevated Cr, Low ... hydration - Hyperkalemia ... #TLS #diagnosis
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
• Metabolic alkalosis ... • Diagnosis of ... Hyponatremia • Hypercalcemia ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology
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