12 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... syndrome - Mutation ... (renal potassium ... #nephrology #management ... #pathophysiology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Aldosterone: Liddle's Syndrome ... SAME, Cushing Syndrome ... , Bartter syndrome ... , Gitelman syndrom ... #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... - Urinary Chloride ... use, Bartter syndrome ... , Gitelman syndrome ... #Urinary #Chloride
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... , Bartter's syndrome ... , Gitelman's syndrome ... acid, Liddle's syndrome ... #nephrology #potassium
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Syndrome, Gitelman ... Syndrome Volume ... GRA, Cushing's syndrome ... , Liddle syndrome
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... Severe Cushing syndrome ... Congenital AME syndrome ... syndrome (defective ... calcium) alkali syndrome
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
acid, Liddle's Syndrome ... R - Cushing's syndrome ... , Bartter's syndrome ... , Gitelman's syndrome ... #causes #low #potassium
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... , Bartter's syndrome ... use), Gitelman's ... syndrome (mimics ... excess and related syndromes
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
suggests extra-renal ... ↓ Aldosterone: Syndrome ... excess, Liddle's syndrome ... syndrome, Gitelman ... syndrome -
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypokalemia - Hypomagnesemia ... - Metabolic Alkalosis ... #Syndrome #Diagnosis ... #Workup #nephrology