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differential injury causes hepatitis transaminitis abnormal chemistry drug druginduced enzymes fatty gastroenterology hepatocellular idiosyncratic induced interpretation liverenzymes malignant management nafld
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... gastroenterology #algorithm ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... Algorithm DILI ... disease, Hepatic ... disorder (e.g. ascites ... #Algorithm #hepatology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
- Differential Diagnosis ... Algorithm Portal ... • Infiltrative disease ... • Acute liver ... #Algorithm #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... • Iatrogenic: DILI ... #differential #diagnosis ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential Diagnosis ... Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... #hepatology #algorithm ... Transaminitis #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Algorithm Severe ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... disease: > 2 ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... disease; AST, aspartate ... disease; T2DM, ... #LFTs #Abnormal ... #Algorithm #Hepatology
Non-Alcoholic Fatty Liver Disease (NAFLD) - Diagnosis Algorithm Low Suspicion: ≤ 1 feature of
Disease (NAFLD) ... - Diagnosis Algorithm ... Suspicion: ≤ 1 feature ... #Diagnosis #Algorithm ... #hepatology
Common Malignancies That Cause Ascites The most common malignancies causing ascites are ovarian cancer, pancreatic cancer, gastric
Cancer - Advanced disease ... carcinomatosis or liver ... peritoneum or liver ... #Differential #Diagnosis ... #Hepatology #oncology
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