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differential causes management treatment nephrology erythematosus lupus rheumatology systemic algorithm blood cerebritis classification cns disorders druginduced k leukostasis lysis neurology
Causes of Hyperkalemia Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
caused by excess potassium ... transcellular shifts ... renal function, medication ... is rarely the sole ... dysfunction is common #Diagnosis
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 Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
shift of K (Succinylcholine ... #differential #diagnosis ... #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... insufficiency/Failure • SLE ... Medications 2.
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... insufficiency/Failure • SLE ... Medications 2.
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... and ECG changes ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
- Differential Diagnosis ... Framework • Cellular Shift ... hyperosmolality - Medications ... #Causes #potassium ... #high
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
- Differential Diagnosis ... Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Induction Rx: high-dose ... Erythematosus #SLE
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... family history - Medications ... function test, ANA (e.g ... ., SLE), anti-phospholipid ... psychiatric changes), high
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... hydration - Hyperkalemia ... unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
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