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differential management causes erythematosus nephrology rheumatology sle systemic treatment algorithm blood cerebritis classification cns druginduced leukostasis lysis neurology pharmacology product
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
shift of K (Succinylcholine ... #differential #diagnosis ... #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... and ECG changes ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... Medications 2. ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... phlebotomy High ... Intracellular Shift ... Medications 2. ... #high #nephrology
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
- Differential Diagnosis ... Framework • Cellular Shift ... hyperosmolality - Medications ... #Causes #potassium ... #high
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... permeability Diagnosis ... Lumbar Puncture, EEG ... Induction Rx: high-dose ... #cerebritis #diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
immature blasts and high ... hydration - Hyperkalemia ... unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
complements and a high ... Differential Diagnosis ... vein thrombosis Hematologic ... activation and/or medications ... Erythematosus #Diagnosis
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Causes of Hyperkalemia ... extracellular shift ... diseases: syßtemic lupus ... #Differential #Diagnosis ... #High #Potassium
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Epidemiology 1) High ... survival is 93-95% Pathophysiology ... hyperphosphatemia, hypercalcemia ... (e.g. incidental ... skin (16-32%): lupus
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