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diagnosis management algorithm differential causes nephrology neurology syndrome blood cerebritis cns druginduced encephalopathy erythematosus evaluation hypokalemia k kdigo leukostasis lupus
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC ... shift of K (Succinylcholine ... differential #diagnosis #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Medications for the Treatment of Hyperkalemia The goals of acute treatment are to prevent potentially life-threatening cardiac
Medications for ... disturbances, shift ... , changes on ECG ... Table 3 summarizes medications ... #Management #Medications
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 Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... and ECG changes ... blocks, QRS axis shift ... #potassium #high ... management #algorithm #treatment
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
• Reconsider treatment ... and parenteral potassium ... Intracellular K+ Shift ... Management #Algorithm #treatment ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Intracellular Shift ... Medications 2. ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Intracellular Shift ... Medications 2. ... #high #nephrology
Emergent Hyperkalemia Treatment Algorithm ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... ECG changes, weakness ... injury, etc) ECG ... cardiac membrane Shift ... Remove potassium
Thyrotoxic Periodic Paralysis - Illness Script • Epidemiology: Asian men age 20-30 with hyperthyroidism of any
and menses • Pathophysiology ... Labs/lmaging: Hypokalemia ... fT4 or high T3 ... • Treatment: Potassium ... hyperthyroidism, Potassium
Causes of Hyperkalemia - Differential Diagnosis Framework • Cellular Shift: - Exercise
Causes of Hyperkalemia ... Framework • Cellular Shift ... hyperosmolality - Medications ... Diagnosis #Causes #potassium ... #high
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... immature blasts and high ... hydration - Hyperkalemia ... unless worrisome EKG ... diagnosis #management #hematology
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