18 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
edgarvlermamd #Potassium ... #Binding #KBinders ... Comparison #Table #Pharmacology ... #Patiromer #HyperKalemia ... #Nephrology #Agents
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
Binder INDICATION ... oral suspension DOSING ... binder that can ... #Binder #KBinder ... Pharmacology
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... calcium for K; also binds ... nonspecifically binds ... #medications #pharmacology ... table #comparison #binders
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... #Binders #Management ... #Hyperkalemia # ... treatment #pharmacology ... table #comparison #nephrology
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
Phosphate binders ... aluminum-based phosphate binder ... calcium-based phosphate binders ... Only* #CKD #Nephrology ... #Pharmacology #
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
Hyperkalemia - Management ... • Consider K+ binder ... and ECG changes ... blocks, QRS axis shift ... #potassium #high
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
Used Phosphate Binders ... edgarvlermamd - Nephrology ... #Phosphate #Binders ... Table #Comparison #Pharmacology ... #Nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Clenching of fist during ... • Recent IV potassium ... Intracellular Shift ... diagnosis #causes #potassium ... #high #nephrology
KDIGO Treatment algorithm for management of acute hyperkalemia in the emergency department
 • Place on cardiac
management of acute hyperkalemia ... monitor 12-lead ECG ... • Consider K+ binder ... algorithm #treatment #potassium ... #high #nephrology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... - Hyperkalemia ( ... Because digoxin binds ... , in states of hypokalemia ... can more easily bind