20 results
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
action on the nephron ... Loop diuretic (e.g ... triamterene) #nephron ... #diuretics #pharmacology ... #nephrology #medications
IV Fluid Composition and Effects on Plasma
0.9% Saline
Ringer's Lactate
Balanced Crystalloid

#IVFluid #Composition #Plasma #comparison #Effects #nephrology #pharmacology
Composition and Effects ... Composition #Plasma #comparison ... #Effects #nephrology ... #pharmacology
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
NSAIDS and their effects ... distal component of Nephron ... hyporenin hypoaldo, hyperkalemic ... absorption in distal nephron ... KidneyDisease #nephrology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... ) Loop agents (eg ... Adenosine #Nephron ... Sites #Action #nephrology ... #pharmacology
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
KBinders #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia ... #Nephrology #Agents
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
15 g QD • Side Effects ... 8.4 g • Side Effects ... daily • Side Effects ... #medications #pharmacology ... #table #comparison
Beta Blocker Side Effects / Toxicity
Cardiac Side Effects:
 • Sinus bradycardia, AV block, Heart failure exacerbation,
Beta Blocker Side Effects ... Toxicity Cardiac Side Effects ... withdrawal syndrome (e.g ... Facilitation of hyperkalemia ... AdverseEffects #pharmacology
Common Vasopressors and Inotropes
Norepinephrine (NE)
 - Indication: Distributive shock (1st line for septic shock), Cardiogenic shock
mild ↑CO) - Side effects ... is not desired (e.g ... is not desired (e.g ... Vasopressors #Inotropes #comparison ... #table #pharmacology
Effects of Prostaglandins and NSAIDs on the Kidney
Effects of Prostaglandins on the Kidney:
 • The vasodilatory
Effects of Prostaglandins ... on the Kidney Effects ... perfusion of remaining nephrons ... Kidney #renal #nephrology ... #pharmacology
Emergent Hyperkalemia Treatment Algorithm
ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... injury, etc) ECG ... cardiac membrane Shift ... insulin Side effect ... not quickly) #Hyperkalemia