28 results
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites of action ... on the nephron ... Metolazone) 5) Potassium-sparing ... #diuretics #pharmacology ... #nephrology #medications
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Hormones Acting ... on the Nephron - ... Their Site of Action ... HCTZ) 5) Potassium-sparing ... Pathophysiology #Nephrology
Causes of Hyperkalemia - Differential Diagnosis Algorithm
 • Increased Intake
 • Reduced Excretion (IV potassium with
Causes of Hyperkalemia ... Excretion (IV potassium ... Transcellular Shift ... #Hyperkalemia ... #Nephrology #Differential
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift ... GI losses (NG suction ... Diagnosis #Algorithm #nephrology ... #low #potassium
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... Diuretic Sites of Action ... ) Loop agents (eg ... Adenosine #Nephron ... #nephrology #pharmacology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Causes of High-anion ... Hypokalemia ... Generalized distal nephron ... Potassium-sparing ... #nephrology
Constipation - Differential Diagnosis Algorithm
Diet/Lifestyle
 • Fibre
 • Calories
 • Fluid
 • Exercise
 • Psychosocial
Medications
 •
Medications • Neurally Active ... Aluminum, Calcium, Potassium ... Hypothyroidism • Hypokalemia ... • Hypercalcemia ... Diagnosis #Algorithm #Causes
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Recent IV potassium ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... intracellular calcium causes ... - Hyperkalemia ( ... , in states of hypokalemia ... CaitEKulig #Digoxin #Pharmacology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• Recent IV potassium ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high ... #nephrology