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diagnosis differential treatment high medications nephrology algorithm anesthesiology checklist comparison intraoperative rhabdomyolysis workup aldosterone angiotensin antifungals antiobesity bradycardia cardiacarrest cardiology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... Hyperkalemia ... • Increased EC shift ... pathophysiology #pharmacology ... #potassium #medications
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... shift - Acidosis ... drugs - Transfusion ... Renal failure* - Drugs—potassium-sparing ... #Causes #diagnosis
Here’s a review of the Renin-Angiotensin-Aldosterone system (RAAS) This is a very common pathway that clinicians should
sodium, which causes ... RAAS inhibiting drug ... avoid harmful hyperkalemia ... RAAS inhibiting drugs ... ReninAngiotensinAldosteroneSystem #RAAS #Pharmacology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
reactions Common Drugs ... • Recent IV potassium ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
Hyperkalemia Management ... • Treat the cause ... and parenteral potassium ... Intracellular K+ Shift ... #treatment #potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
reactions Common Drugs ... • Recent IV potassium ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... Summary Causes ... - Toxins - Drugs ... Shift of extracellular ... Monitor potassium
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Drugs (Statins), ... Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia ... #Summary #causes
Cardiac Arrest - Guidelines for Crises in Anaesthesia The probable cause is one or more of: something
reminders about drugs ... Hypovolaemia Hypo/hyperkalaemia ... : Vagal tone Drug ... Anesthesiology #Anesthesia ... Checklist #Diagnosis #Management
Intraoperative Bradycardia - Guidelines for Crises in Anaesthesia Bradycardia in theatre should not be treated as
could have made a drug ... Consider known drug ... causes (eg. remifentanil ... myocardial infarction, hyperkalaemia ... Checklist #Diagnosis #Management
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