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Causes of Hyperkalemia Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
Causes of Hyperkalemia ... is caused by excess ... potassium intake ... transcellular shifts ... dysfunction is common #Diagnosis
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 Causes of Hyperkalemia - Differential Diagnosis Algorithm • Increased Intake • Reduced Excretion (IV potassium with
Causes of Hyperkalemia ... - Differential Diagnosis ... Excretion (IV potassium ... Transcellular Shift ... #Hyperkalemia
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Causes of Hypokalemia ... - Differential Diagnosis ... Transcellular Shift ... #Algorithm #causes ... #potassium #low
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... #differential #diagnosis ... pathophysiology #pharmacology ... #potassium #medications
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
• Treat the cause ... • Reconsider treatment ... and parenteral potassium ... Intracellular K+ Shift ... #potassium #high
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... ); nausea, vomiting ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... Management of Hyperkalemia ... cyclosilicate #Potassium ... #treatment #pharmacology ... #table #comparison
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... blocks, QRS axis shift ... #potassium #high ... #diagnosis #management ... #algorithm #treatment
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... • Recent IV potassium ... Intracellular Shift ... #differential #diagnosis ... #causes #potassium
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... shift - Acidosis ... intoxication - Hyperkalemic ... acidosis) #Hyperkalemia ... #Causes #diagnosis
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