54 results
Antiarrhythmic Drugs

CLASS IA
 • Procainamide, Quinidine, Disopyramide
CLASS 1B
 • Lidocaine, Mexiletine
CLASS 2
 • Propranolol, Esmolol
CLASS 4
Antiarrhythmic Drugs ... • Adenosine, Magnesium ... , Potassium # ... Medications #Classes ... Classification #Pharmacology
Causes of Hyperkalemia

Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
Causes of Hyperkalemia ... is caused by excess ... potassium intake ... , impaired potassium ... transcellular shifts
Causes of Hyperkalemia - Differential Diagnosis Algorithm
 • Increased Intake
 • Reduced Excretion (IV potassium with
Causes of Hyperkalemia ... Excretion (IV potassium ... Transcellular Shift ... #Hyperkalemia ... Diagnosis #Algorithm #Causes
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift ... vomiting) • Low ... Transcellular shifts ... #potassium
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... Transcellular Shift ... Refeeding Syndrome #Hypokalemia ... Diagnosis #Algorithm #causes ... #potassium #low
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... K; also binds magnesium ... nonspecifically binds K, magnesium ... of aspiration #Potassium ... #medications #pharmacology
Approach to Hypomagnesemia 

Fractional excretion of magnesium = (urine magnesium x serum creatinine)/ [0.7 (serum magnesium
= (urine magnesium ... intake, Gl loss, shift ... of magnesium into ... differential #diagnosis #causes ... #low
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
treated with IV potassium ... (K) & magnesium( ... wasting from other causes ... consumption • Low ... #nephrology #low
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... • Increased EC shift ... MunerMohamed1 #hyperkalemia ... pathophysiology #pharmacology ... #potassium #medications
Potassium Electrolyte Repletion
If patient also has hypomagnesemia, replete magnesium before repleting potassium
Oral:
 • Pills (ask pharmacy
Potassium Electrolyte ... hypomagnesemia, replete magnesium ... before repleting potassium ... Intravenous (can cause ... Repletion #management #hypokalemia