32 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
Potassium #Binding #KBinders ... Comparison #Table #Pharmacology ... #Patiromer #HyperKalemia ... #Nephrology #Agents
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
calcium for K; also binds ... nonspecifically binds ... patients sensitive to high ... #medications #pharmacology ... table #comparison #binders
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... Management of Hyperkalemia ... #Management #Hyperkalemia ... #treatment #pharmacology ... table #comparison #nephrology
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
Phosphate binders ... aluminum-based phosphate binder ... restricted due to hypercalcemia ... Only* #CKD #Nephrology ... #Dose #Dosing #Pharmacology
Hyperkalemia - Management Algorithm
 • IV calcium
 • IV insulin and glucose and/or salbutamolt
 • Consider
Hyperkalemia - Management ... • Consider K+ binder ... blocks, QRS axis shift ... #potassium #high ... management #algorithm #treatment
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... • IV Fluids Shift ... LouLectures #Hyperkalemia ... management #potassium #nephrology
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
MECHANISM: Potassium Binder ... INDICATION: Treatment ... of Hyperkalemia ... #KBinder #Hyperkalemia ... #Pharmacology
Characteristics of Commonly Used Phosphate Binders 
Aluminum 
 - Potent and effective 
 - Useful for
Used Phosphate Binders ... edgarvlermamd - Nephrology ... #Phosphate #Binders ... Table #Comparison #Pharmacology ... #Nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... phlebotomy High ... Intracellular Shift ... causes #potassium #high ... #nephrology
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
associated with hypokalemia ... hypomagnesemia Hypokalemia ... - Shift from extracellular ... - Insulin (high ... differential #diagnosis #nephrology