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diagnosis hyperkalemia differential management nephrology algorithm pharmacology classification pathophysiology rhabdomyolysis anesthesia anesthesiology anthracycline binders binding cardiac cardiotoxicity checklist chemotherapy complexes
Hyperkalemia Management Algorithm • Treat the cause & optimize hemodynamics and ventilation • Reconsider treatment leadingto
• Treat the cause ... • Reconsider treatment ... and parenteral potassium ... Intracellular K+ Shift ... #potassium #high
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
complications such as arrhythmias ... treated with IV potassium ... wasting from other causes ... suggests extra-renal causes ... urinary losses: • High
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... ); nausea, vomiting ... patients sensitive to high ... of aspiration #Potassium ... pharmacology #table #comparison
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... Dialysis Serum potassium ... blocks, QRS axis shift ... #potassium #high ... management #algorithm #treatment
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
phlebotomy High ... • Recent IV potassium ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Weakness, cramping, nausea ... , bradycardia, arrhythmias ... only if no clear cause ... dose PRN (ongoing arrhythmia ... #potassium #nephrology
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
intracellular calcium causes ... - Hyperkalemia ( ... high potassium levels ... , in states of hypokalemia ... Pathophysiology #cardiology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Management Summary Causes ... Shift of extracellular ... Treatment of underlying ... Monitor potassium ... Diagnosis #Management #causes
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Shift of extracellular ... Monitor potassium ... Dialysis for severe hyperkalemia ... Management #Summary #causes ... #treatment
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