12 results
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
works by directly binding ... intracellular calcium causes ... high potassium levels ... binds to the same ... (or low potassium
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
: • Digoxin ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
: • Digoxin ... Intracellular Shift ... differential #diagnosis #causes ... #potassium #high ... #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Calcineurin inhibitors, Digoxin ... only if no clear cause ... acidosis) • Low ... : • K-Binding ... #potassium #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Management Summary Causes ... Shift of extracellular ... fluid/Lactated ringers ... Monitor potassium ... #treatment #nephrology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
WBC count cause ... , Elevated Cr, Low ... hydration - Hyperkalemia ... Non calcium phos binders ... diagnosis #management #hematology
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
130 mEq/L • Potassium ... Is Dangerous in Hyperkalemia ... transcellular shift ... • Saline Causes ... densa receives high
Premature Ventricular Complexes (PVC's) - Summary Framework

Why PVCs?  Can be the first manifestation of cardiac
heart disease Causes ... Hypomagnesemia • Hypokalemia ... Substances • Digoxin ... classified as: • Low ... more intensive treatment
Complications after Bariatric Surgery
Post Bariatric Intestinal Failure:
 • Severe protein malnutrition after bariatric surgery
 • More
, but high complication ... Tx: Small and low ... Gastric bypass causes ... absorption, calcium binds ... oral calcium, potassium
Causes of Hyperkalemia
l. Pseudohyperkalemia
  A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis
  B.
Causes of Hyperkalemia ... extracellular shift ... Digoxin and related ... Differential #Diagnosis #High ... #Potassium #Classification