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diagnosis hyperkalemia causes medications treatment high nephrology comparison drugs rhabdomyolysis table algorithm anemia binder channelblockers classification druginduced effects helicobacter hemolytic
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Increased EC shift ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Veltassa (Patiromer) MECHANISM: Potassium Binder INDICATION: Treatment of Hyperkalemia FORMULATION: Powder for oral suspension DOSING: 8.4
Binder INDICATION ... from other oral drugs ... this from other drugs ... #Binder #KBinder ... #Hyperkalemia #Pharmacology
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... • Consider K+ binder ... Dialysis Serum potassium ... blocks, QRS axis shift ... #hyperkalemia #potassium
Potassium Channel Blockers - Medications 1. Cardiovascular Drugs 2. Psychiatric drugs 3. Other drugs 4. Synthetic opioids: Levomethadyl 5. Opium
Potassium Channel ... Other drugs 4. ... Organophosphates #Potassium ... #Medications #Differential ... #Diagnosis #Pharmacology
Drugs Implicated in Hemolytic Anemia • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Drugs Implicated ... Anemia • Hapten (Drug ... complex binds to ... Hemolytic #Anemia #differential ... #diagnosis #pharmacology
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... for Management ... cyclosilicate #Potassium ... #Binders #Management ... Hyperkalemia #treatment #pharmacology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Rhabdomyolysis - Differential ... Diagnosis and Management ... Drugs (Statins), ... Shift of extracellular ... Monitor potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... • Recent IV potassium ... Intracellular Shift ... #hyperkalemia #differential
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... • Recent IV potassium ... Intracellular Shift ... #hyperkalemia #differential
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Framework and Management ... - Toxins - Drugs ... Shift of extracellular ... Monitor potassium
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