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diagnosis hyperkalemia medications nephrology treatment high rhabdomyolysis table binding classification druginduced drugs effects helicobacter hpylori hypomagnesemia hypomg induced lactated lr
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... • Increased EC shift ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Potassium Binders for Management of Hyperkalemia • SPS - Sodium polystyrene sulfonate • Patiromer (veltassa) •
Potassium Binders ... for Management ... #Binders #Management ... Hyperkalemia #treatment #pharmacology ... #table #comparison
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... of aspiration #Potassium ... #medications #pharmacology ... #table #comparison ... #binders
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison Composition of LR: • Sodium 130 mEq/L •
Saline (NS) - Comparison ... 130 mEq/L • Potassium ... transcellular shift ... • Saline Causes ... #pharmacology #
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Diagnosis and Management ... Drugs (Statins), ... Shift of extracellular ... Monitor potassium ... #Summary #causes
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... Intracellular Shift ... #diagnosis #causes ... #potassium #high
Causes of Hypomagnesemia Redistribution: - IV glucose - Correction of diabetic ketoacidosis - IV hyperalimentation - Refeeding
Causes of Hypomagnesemia ... osmotic diuresis - Potassium ... renal disease Drugs ... #diagnosis #differential ... #pharmacology #
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... Summary Causes ... - Toxins - Drugs ... Shift of extracellular ... Monitor potassium
Causes of Hyperkalemia Pseudohyperkalemia - Tourniquet use - Hemolysis (in vitro) - Leukocytosis - Thrombocytosis Intra- to extracellular
Causes of Hyperkalemia ... shift - Acidosis ... Renal failure* - Drugs—potassium-sparing ... #Hyperkalemia #Causes ... #diagnosis #differential
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... reactions Common Drugs ... Intracellular Shift ... #diagnosis #causes ... #potassium #high
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