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Hyperkalemia Hypokalemia - Differential Diagnosis and Management Algorithm

Dr Pravin Patel

#Hypokalemia #Hyperkalemia #potassium #differential #diagnosis #management
Hyperkalemia Hypokalemia ... - Differential ... Diagnosis and Management ... potassium #differential ... #diagnosis #management
Causes of Hyperkalemia - Differential Diagnosis Algorithm
 • Increased Intake
 • Reduced Excretion (IV potassium with
Causes of Hyperkalemia ... - Differential ... Excretion (IV potassium ... Transcellular Shift ... #Hyperkalemia
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... #differential # ... diagnosis #pathophysiology ... #pharmacology # ... potassium #medications
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
of Old and New Potassium-Binding ... edgarvlermamd #Potassium ... #Binding #KBinders ... Comparison #Table #Pharmacology ... #Patiromer #HyperKalemia
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... - Differential ... Transcellular Shift ... Algorithm #causes #potassium ... #low #pathophysiology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift ... Transcellular shifts ... #Differential # ... nephrology #low #potassium
Potassium Binders for Management of Hyperkalemia
 • SPS - Sodium polystyrene sulfonate
 • Patiromer (veltassa)
 •
Potassium Binders ... for Management ... of Hyperkalemia ... #Binders #Management ... treatment #pharmacology
Causes of Hyperkalemia

Hyperkalemia is caused by excess potassium intake, impaired potassium excretion, or transcellular shifts. The
caused by excess potassium ... intake, impaired potassium ... transcellular shifts ... adapt to excess potassium ... #Differential #
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... calcium for K; also binds ... nonspecifically binds ... of aspiration #Potassium ... #medications #pharmacology
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... minutes) Decrease potassium ... • IV Fluids Shift ... LouLectures #Hyperkalemia ... #management #potassium