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differential liver injury transaminitis alcoholic anemia chemistry druginduced function gap globulin hematology hepatocellular hospitalization interpretation liverenzymes management pathophysiology protein proteingap
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Liver Function Tests ... Diagnosis Framework ... Hepatopathy • Acute ... (>1000): • DILI ... #Diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular ... Causes of Acute ... • Iatrogenic: DILI ... extrahepatic source - Tests ... #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... - Differential Diagnosis ... #Differential #Diagnosis ... #Causes #Acute ... #algorithm #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... for alternative causes ... Alcohol-related liver disease ... dechallenge • Acute ... #Algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Cholestatic disease ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes ... #Algorithm #Causes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury → liver test ... • Infections: Hepatitis ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... of cholestatic disease ... liver #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... exclude other causes ... - Concomitant diseases ... HCV, DILI, HCC, ... #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Viral infections (acute ... , PBC, PSC, Viral ... inflammation (acute ... #differential #diagnosis ... #hematology
Anemia of Hospitalization - Pathophysiology Why does the Hgb/Hct drop in the first two days during hospitalization? Interestingly,
These shifts of ... blood loss or acute ... of unnecessary diagnostic ... Anemia of renal disease ... #differential #diagnosis
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