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diagnosis differential hematology oncology vasculitis algorithm amyloid amyloidosis classification dermatology eosinophilia erythematosus gap globulin immunology leukemia lupus lymphocytic mds myelodysplasia
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Eosinophilia - Differential ... GI, lung, skin), ... histiocytosis • Allergic ... insufficiency, Chronic ... #Eosinophilia #Differential
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Hepatomegaly • Skin ... lymphoproliferative disorders ... • Richter’s Syndrome ... #Chronic #Lymphocytic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... - Affects the skin ... Cryoglobulinemic Vasculitis - Skin ... glomerular ischemia - Skin ... Small Vessels: Skin
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
Eosinophilic GI Disorders ... Causes: • Mast cell ... activation syndrome ... #Diagnosis #hematology ... #allergy
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... just beneath the skin ... Marrow Failure • Chronic ... Neutropenia • Platelet Disorders ... blood count with differential
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Summary Group of disorders ... : • Nephrotic syndrome ... Infiltration of muscles Skin ... waxy or thickened skin ... Tests: • Nerve
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... Seizures • Strokes Skin ... with Lupus: • Chronic
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... commonly affects the skin ... • Affects the skin ... cmpkx deposits skin ... Vasculitis: • Skin
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
an exaggerated skin ... Skin trauma → Erythematous ... • Chronic myeloid ... What is the skin ... #dermatology #skin
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
myeloma • Plasma cell ... gammopathy, and skin ... changes (POEMS syndrome ... Connective tissue disorders ... Gap #ProteinGap #differential
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