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management differential signs symptoms disease erythematosus lupus sle syndrome vasculitis adultonset arteritis autoimmune chronic classification cll dermatology gca giantcell hand
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Sjögrens (15%) Skin ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... response to local skin ... retinal damage) • Skin ... test (this is a skin ... #management #signs
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Purpura, ischemic skin ... - Affects the skin ... Diagnosis: Systemic ... Small Vessels: Skin ... #diagnosis #rheumatology
Lymphocutaneous Sporotrichiosis Infection Landscaper w/ painless nodular rash of arm present for months wax and wane; diagnosis? Lymphocutaneous
wax and wane; diagnosis ... trauma leads to skin ... , painless, no systemic ... signs, labs normal ... #photo #hand
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... Arthralgia/arthritis, Skin ... fraction < 20% Differential ... solid cancers • Systemic ... management #treatment #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... Diagnosis: • Systemic ... cmpkx deposits skin ... Vasculitis: • Skin ... #Diagnosis #Rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... signs/sx of inflammation ... very remarkable w/differential ... required due to skip ... them, but urgent rheumatology
Secondary Syphilis Rash Secondary syphilis is the most contagious of all the stages of this disease, and
characterized by a systemic ... Skin rash and malaise ... The signs and symptoms ... Syphilis #Rash #Diagnosis ... #Clinical #Photo
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... salivary ducts Clinical ... myelopathy, cranial nerve ... amyloidosis, PAH Skin ... : • Dry skin (xerosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Orange or Hep C Clinical ... Physical Exam/Signs ... Hepatomegaly • Skin ... ’s CLL Scoring system
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