39 results
Leg Pain - Differential Diagnosis Framework

Bone/Joint Causes of Leg Pain:
 • Fracture
 • Arthritis
 • Gout/pseudogout
Leg Pain - Differential ... thrombophlebitis Skin ... • Shin splints ... Brittle nails - Skin ... skin • Inflammation
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
and signs. ... malaise, Weight gain ... , Dry coarse skin ... Carpal timel syndrome ... Goitre), Dry skin
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
Femoral Cutaneous Nerve ... purely sensory nerve ... MeralgiaParesthetica #MSK #pathophysiology ... #differential # ... diagnosis #signs
Cushing Syndrome - Signs and Symptoms
Generalized: Weight gain, Slow healing of cuts, Increased risk of infections,
Cushing Syndrome ... - Signs and Symptoms ... Generalized: Weight gain ... Muscular: Weakness Skin ... #Signs #Symptoms
CREST Syndrome: Pathogenesis and Clinical Findings

CALCINOSIS (BB-sized, hard nodules in fingers)
RAYNAUD'S Phenomenon
ESOPHAGEAL DYSMOTILITY
SCLERODACTYLY (thickening and tightening
CREST Syndrome: ... tightening of skin ... #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Pathyophysiology - hyperglycemic crises in patients with diabetes 
Key signs/symptoms of HHS/DKA:
Both: Polyuria, polydipsia, weight loss,
Pathyophysiology ... diabetes Key signs ... /symptoms of HHS ... hypovolemia (dry MM, skin ... diffuse abdominal pain
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... lumbar spine Signs ... damage to sacral nerves ... #MSK #pathophysiology ... #signs
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
/ Symptoms: - ... Xeroderma (Dry skin ... #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Clinical manifestations of anaphylaxis. 
Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache
Angioedema: Lips, tongue, orbit,
intestines, extremities Skin ... (Skin and Mucosa ... arrest, Kounis syndrome ... edema, abdominal pain ... #anaphylaxis #signs
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin ... Inflammation of skin ... granulomas under skin ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms