39 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
workup for specific symptoms ... glucocorticoid treatment ... (eg, skin or esophageal ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Sarcoidosis 
Non-caseating granulomas (Composed of T-helper & inflammatory cells) 
Clinical:
 • Disease fatal in 10% of
exertion • Neurologic ... neuropathies • Skin ... dysrhythmias • Ophthalmologic ... Sarcoidosis #Diagnosis #Symptoms
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
response to local skin ... injury) • Neurologic ... retinal damage) • Skin ... test (this is a skin ... #rheumatology #
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Arthralgia/arthritis, Skin ... fraction < 20% Differential ... diagnosis #management #treatment ... #rheumatology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
pattern of spread, B symptoms ... Responsive to Treatment ... Classification #pathophysiology ... #Hematology #Diagnosis ... #NonHodgkin #differential
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
characterized by extensive skin ... Symptoms: • The ... Skin involvement ... Resolution > 15 days Differentials ... disease: symptomatic treatment
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Rheumatologic ... osteomyelitis or skin ... Aspergillosis Pathophysiology ... organism into the skin ... Mouth, throat, skin
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Purpura, ischemic skin ... commonly affects the skin ... • Affects the skin ... cmpkx deposits skin ... Vasculitis: • Skin
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
arterial thrombosis, skin ... ♀, ↑Age, ESRD Pathophysiology ... exposure (prevent skin ... Diagnosis #Management #Treatment ... #Hematology #HemeOnc
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
integrity of: • Skin ... musculoskeletal symptoms ... Psychiatric symptoms ... Muscle cramping Skin ... vasculitis Treatment