15 results
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune ... LcSSc) - distal skin ... DcSSc; diffuse) - skin ... changes): skin ... Scleroderma #SSc #rheumatology
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Ill-appearing, vital sign ... sulfa-drug - Skin ... #Dermatology #Rash ... Targetoid #Algorithm #Differential ... #Ddxof
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Autoimmune diseases ... trigger - Direct skin ... 50% of patients Skin ... 1% of patients Skin ... #comparison #table
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Joint Disorders - Differential ... arthritis - with the skin ... formation, systemic autoimmune ... should have other symptoms ... like “butterfly rash
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
organ-specific signs ... or symptoms (eg ... , skin or esophageal ... Disorders #Algorithm #Differential ... #diagnosis #hematology
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
centrifugum • A chronic skin ... gyratum repens • A skin ... induratum • A chronic skin ... Erythemas #comparison #table ... #differential #
Highlighted Conditions With Arteritis or Periarteritis of the Coronaries
Takayasu's arteritis:
 - Onset < 40 yrs
 -
yrs - Cranial symptoms ... Polyarteritis nodosa: - Skin ... Retroperitoneal fibrosis - Autoimmune ... Coronaries #Arteritis #Differential ... Diagnosis #Cardiology #Table
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
response to local skin ... retinal damage) • Skin ... test (this is a skin ... Behcet disease) Differential ... #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... rheumatologic diseases ... Seizures • Strokes Skin ... Induced Lupus: • Symptoms