13 results
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Insufficiency Addison's Disease ... aldosterone Causes ... : Most Common Causes ... disorder - Primary hypothyroidism ... #endocrinology
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
hypotension - Nausea ... Autoimmune thyroid disease ... - Secondary hypothyroidism ... Insufficiency #Signs ... #Symptoms #Adrenal
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
• Cushing's Disease ... Dwarfism) • Hypothyroidism ... • Congenital Adrenal ... Diagnosis #Algorithm #endocrinology ... #causes #pediatrics
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
goiter (Graves' disease ... TRAb) if Graves' disease ... #causes #diagnosis ... #differential #endocrinology ... #signs #symptoms
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
hypertension and signs ... bruit or signs ... Vasculitis • Endocrinologic ... : Hypothyroidism ... disease: CKD, acute
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings
Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... 21-OHD in the adrenal ... Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology ... #peds #pediatrics
Biphasic Illness of Leptospirosis
Some patients do not progress to severe disease. Others, rapidly develop severe disease
brief interval symptom ... rash • Others: nausea ... (renal + hepatic ... dysfunction) • Pulmonary ... Diagnosis #Illness #Signs
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Malnutrition • Wilson's disease ... • hypothyroidism ... mineralization Symptoms ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features
1) Skin
 • Thin, easily bruisable skin with
, oral cavity) Caused ... the abdomen for adrenal ... tumors • The adrenal ... Hypercortisolism #Diagnosis #signs ... #symptoms #endocrinology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
progressing GN • New pulmonary ... glomerulonephritis and/or pulmonary ... tract, and often causes ... Presentation - Systemic Symptoms ... purpura: strong sign