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diagnosis hematology mds myelodysplastic anemia chronic classification cvid differential gap globulin hodgkins hypogammaglobulinemia immunodeficiency immunology lymphoma myelodysplasia protein proteingap sweet
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Cancer affecting ... : • Most common ... Hepatomegaly • Skin ... aplasia • ITP ... #Lymphocytic #Leukemia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemia): • Lymphocytes ... Leukemia): • Lymphocytes ... lymphoid organs When Cancer ... -> Invade Skin: ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... transformation to acute leukemia ... Allogeneic stem cell ... #oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Internal organs Most common ... general feeling of ill ... Causes: - Idiopathic ... #diagnosis #dermatology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... virus (EBV) • Leukemia ... #Anemia #oncology ... #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Most common cytopenia ... • Anemia • Aplastic ... Cell Leukemia ... #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... Lymphoma or other cancers ... gastric and breast cancer ... Granulomatous lymphocytic ... DDX - Other causes
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... (NSHL) - (most common ... HL (MCHL) - Lymphocyte ... classification #hematology ... #oncology #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
leukemia • Solitary ... gammopathy, and skin ... changes (POEMS syndrome ... ovarian tumors, lung cancers ... Comment on type
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