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diagnosis symptoms hematology leukemia lupus management oncology sle systemic arteritis chronic classification cll cryoglobulinemia cryoglobulins dermatomyositis differential dm gca giantcell
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... and Clinical Findings ... • Primary Sjögren's ... ) #Primary #Sjogrens ... #Syndrome #Pathophysiology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... (15%) Skin (85% ... Butterfly rash, Vasculitis ... Demyelinating syndromes ... #signs #symptoms
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... Orange or Hep C Clinical ... Physical Exam/Signs ... Hepatomegaly • Skin ... • Richter’s Syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... dermatomyositis, Sjogren ... the context of primary ... Clinical Features
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... glands: • Focal lymphocytic ... salivary ducts Clinical ... ) • Cutaneous vasculitis ... #Syndrome #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... : • Clinical triad ... reticularis & skin ... systemic lupus erythematosus ... classification #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
+ distinctive primary ... • Tumor lysis syndrome ... lymphoid organs When Cancer ... CLL -> Invade Skin ... Transformation: • Complication
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... with GCA or as primary ... : Erythematous nodules ... elevated protein, lymphocytic ... Differential #Diagnosis #Rheumatology
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Pathogenesis and clinical ... processes occur in the skin ... diffuse CD8+ T lymphocytes ... #Signs #Symptoms ... #Vasculitis
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
and ophthalmic complications ... Diagnosis = clinical ... systemic sx + signs ... required due to skip ... them, but urgent rheumatology
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