10 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... and Clinical Findings ... • Primary Sjögren's ... ) #Primary #Sjogrens ... #Syndrome #Pathophysiology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... (15%) Skin (85% ... Butterfly rash, Vasculitis ... #erythematosus ... #signs #symptoms
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can activate ... the immune system ... : • Clinical triad ... lupus erythematosus ... classification #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... 3rd Decade Skin ... dermatomyositis, Sjogren ... the context of primary ... Clinical Features
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... salivary ducts Clinical ... Vasculitis: • ... muscarinic agonists • Active ... #Syndrome #Rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
purpura: Strong sign ... with GCA or as primary ... : Erythematous nodules ... Rash, arthritis Primary ... Differential #Diagnosis #Rheumatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... rendering the immune system ... Orange or Hep C Clinical ... Physical Exam/Signs ... Hepatomegaly • Skin
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
inflammatory vasculitis ... and ophthalmic complications ... Diagnosis = clinical ... required due to skip ... them, but urgent rheumatology
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Lymphoma • Lung cancer ... characteristic features Clinical ... Complications: ... • Tuberculin skin
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Lymphoma • Lung cancer ... characteristic features Clinical ... Complications: ... • Tuberculin skin