7 results
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... and Clinical Findings ... • Primary Sjögren's ... ) #Primary #Sjogrens ... #Syndrome #Pathophysiology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... : • Clinical triad ... syndrome - type ... lupus erythematosus ... classification #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... (15%) Skin (85% ... Butterfly rash, Vasculitis ... #erythematosus ... #signs #symptoms
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... 3rd Decade Skin ... dermatomyositis, Sjogren ... Kikuchi disease • Type-I ... the context of primary
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... salivary ducts Clinical ... ) • Cutaneous vasculitis ... Vasculitis: • ... #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
lupus erythematosus ... purpura: strong sign ... C-ANCA) pattern: antibodies ... Serologies for Cryoglobulins ... differential #diagnosis #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Divided Into Two Types ... Primary (essential ... malignancies, vasculitis ... processes: • Systemic ... Antiphospholipid syndrome