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diagnosis acute anemia apl aplastic apml clinical disseminated emergencies hemeonc intravascular myelodysplasia myelodysplastic oncologic pathology promyelocytic rods syndromes treatment
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
(blood). ... features in most cases ... Kyle Bradley, MD ... APML #Pathology #Hematology ... #Clinical #Smear
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
promyelocytic leukemia ... ABO incompatible blood ... • Peripheral smear ... #treatment #management ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
smear or on bone ... Age: 50-60 • Auer ... • Peripheral smear ... Fibrinolysis & DIC ... #Hematology #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... • Hairy Cell Leukemia ... smear • Bone marrow ... Syndromes #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... virus (EBV) • Leukemia ... result from low blood ... #hematology #diagnosis ... #management
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
syndrome): - Hematologic ... G6PD first) DIC ... intravascular coagulation ... Treat underlying cause ... Usually myeloid leukemias
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