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diagnosis myelodysplastic product reactions treatment anemia apl apml chronic clinical cll coagulation dic disseminated intravascular lymphocytic myelodysplasia pathology promyelocytic rods
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
leukemia (blood ... features in most cases ... Kyle Bradley, MD ... APML #Pathology #Hematology ... #Clinical #Smear
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
transformation to acute ... leukemia Management ... Myelodysplastic #Syndrome #MDS ... #treatment #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
smear or on bone ... -> AML: Blast crises ... Age: 50-60 • Auer ... • Peripheral smear ... #Hematology #Oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... virus (EBV) • Leukemia ... result from low blood ... #Anemia #oncology ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Peripheral smear ... Lymphocytosis: Absolute blood ... Pure red cell aplasia ... ’s lymphoma or acute ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Peripheral Smear ... • Anemia • Aplastic ... • Hairy Cell Leukemia ... Syndromes #diagnosis #hematology ... #oncology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... promyelocytic leukemia ... ABO incompatible blood ... • Peripheral smear ... #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
- Acute Hemolytic ... due to marrow aplasia ... by Nick Mark MD ... Transfusions #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Acute Hemolytic ... Transfusion Related Acute ... due to marrow aplasia ... Transfusion #diagnosis #management ... #hematology #reactions
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