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diagnosis neurology differential signs endocrinology hyperthyroidism management acetylcholinereceptor achr algorithm clinical diplopia eyelid infections infectiousdiseases intravenousimmunoglobulin ivig manifestations musclespecificreceptortyrosinekinase musk
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... chewing, loss of smile ... test - Cogan sign ... - Peek sign ... immunologic assay - MuSK
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
Causes of Peripheral ... • Cardio-pulmonary ... Oculomotor • Myasthenia ... Gravis • Lambert-Eaton ... Myasthenic Syndrome
Ocular Myasthenia Gravis on Physical Exam A 41yo female was referred by her neurologist for double vision.
non-localized EOM weakness ... Myasthenia gravis ... such as cogan sign ... tumor, and always ask ... #clinical #video
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 Drugs associated with worsening of Myasthenia Gravis (MG): • D-penicillamine • Botulinum toxin. • Telithromycin • Fluoroquinolones • Quinine • Magnesium • Macrolide antibiotics • Corticosteroids (may cause transient
with worsening of Myasthenia ... Gravis (MG): • ... Corticosteroids (may cause ... higher risk of myasthenic ... because of bulbar weakness
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Weakness • Spinal ... Demyelinating Disease (MS ... Eaton Syndrome, Myasthenia ... Gravis, Organophosphate
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... likely to cause ... or respiratory weakness ... glucocorticoids - can cause ... #Gravis #diagnosis
Hyperthyroidism – symptoms and signs. Symptoms: Weight loss, Increased appetite, Irritability/behaviour change, Restlessness, Malaise, Stiffness, Muscle weakness,
and signs. ... Symptoms: Weight ... Stiffness, Muscle weakness ... hypertension, Cardiac ... Palmar erythema, Graves
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... Sjögren syndrome, Myasthenia ... gravis, Many others ... diagnosis #neurology #symptoms ... #signs
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Non-neuromuscular disorder (Cardiac ... Postsynaptic: Myasthenia ... Gravis - Lack ... of UMN/LMN signs
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
irregularities • Weakness ... Cardiac arrhythmia ... hyperthyroidism #causes ... endocrinology #signs ... #symptoms #thyroid
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