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differential neurology symptoms vasculitis autoimmune classification disorders erythematosus lupus management myopathy scleroderma sclerosis sjogrens sle spinal spinalcord ssc testing vasculitides
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
skin thickening Signs ... (interstitial lung ... acro-osteolysis, myositis ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
effusion, Restrictive lung ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... disorder (Cardiac, pulmonary ... central nervous system ... of the spinal cord ... Lack of UMN/LMN signs
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
- Differential Diagnosis ... • Symptoms and signs ... , Scleroderma, Systemic ... MCTD, Sjogren syndrome ... differential #algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... Conjunctivitis, mucositis ... • Cogan Syndrome ... purpura: strong sign ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... purpura: Strong sign ... Conjunctivitis, mucositis ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
neuropathy, transverse myelitis ... Disease: • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... MALT Lymphoma • Lung ... #Rheumatology #
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system ... #Myopathy #rheumatology
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