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diagnosis antibodies arthritis differential ana classification ra signs workup anca antibody antineutrophil associations autoantibodies cryofibrinogenemia cryoglobulinemia cryoglobulins dermatology erythematosus hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... context of other symptoms ... diseases, but often ... • Rheumatic Diseases ... ANA #patterns #rheumatology
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Scleritis, Heart Disease ... , Rheumatoid Vasculitis ... , Pulmonary Disease ... RA #diagnosis #rheumatology ... #signs #symptoms
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... Anti-TSHR - Graves' disease ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... : • Microscopic ... 90% • Anti-GBM disease ... antibodies #diagnosis #rheumatology ... #diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... diseases, such ... atherosclerotic disease ... most important diseases
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Parenchymal lung disease ... , Pleural disease ... , Airways disease ... and peptic ulcer disease ... Coronary artery disease
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... respectively, having rheumatoid ... Elevated serum rheumatoid ... - GPA, EGPA, microscopic ... classification #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such ... atherosclerotic disease ... most important diseases ... (GRANULOMATOUS DISEASE ... HBV Kawasaki Disease
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... autoantibodies (antinuclear ... antibodies, rheumatoid ... No necrosis, No vasculitis ... IgG4 #Related #Disease
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Diseases • Septic ... polarized light microscopy ... exclude inflammatory disease ... connective-tissue disease ... #Disease #Rheumatoid
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