9 results
Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron

#DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
Drug-Induced Acute ... Kidney Injury - ... AcuteKidneyInjury #AKI ... Pathophysiology #Pharmacology
Medications causing Acute Kidney Injury (AKI)
Prerenal:
 • Dehydration: Diuretics
 • Altered intrarenal autoregulation: ACEIs / ARBs,
Kidney Injury ( ... sphincter tone: • Opiates ... decongestants) • Any drug ... #Drugs #pharmacology ... #differential #diagnosis
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Acute Kidney Injury ... Diagnosis Framework ... Infection-mediated, Drug-induced ... #Acute #Kidney ... #Injury #Differential
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
Liver Injury ... obstruction - Drug-Induced ... liver injury ... #Differential #Hepatology ... #Diagnosis
Vancomycin Associated Acute Kidney Injury

 • Drug induced acute kidney injury is generally defined as a
Drug induced ... acute kidney injury ... 24-72 hours of drug ... #Vancomycin #AKI ... #pharmacology #
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... exposure to HDS, drugs ... non-essential drug ... dechallenge • Acute ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
- Differential Diagnosis ... Hepatopathy • Acute ... 1000): • DILI (Drug-induced ... liver injury) ... #hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
First Generation Anti-Psychotics: Mechanisms and Side Effects
Typical/Conventional Anti-Psychotics - Examples: Haloperidol, Chlorpromazine

ACh M1 antagonist - Block
irreversible • Drug ... induced Parkinsonism ... bradykinesia/akinesia • Acute ... #SideEffects #pharmacology ... #diagnosis #psychiatry