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differential causes rheumatology acidosis activation acute aki algorithm antibodies associations autoantibodies chronic diseases elevation erythematosus fatigue hematology high hyperkalemia injury
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
sphincter tone: • Opiates ... decongestants) • Any drug ... #Medications #Drugs ... #pharmacology # ... differential #diagnosis
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Hematologic • Anemia ... Arthritis • SLE ... Anti-Depressants • Drug ... Alcohol) • Drug ... Malnutrition / Drug
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anti-histone - Drug-induced ... Anti-LKM (liver kidney ... syndrome Anti-Scl ... - Vasculitis, e.g ... Associations #diseases #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... lymphopenia, low PLT • Anemia ... extremities Drug ... • Antihistone: Drug ... Kidney biopsy if
Causes of Hyperkalemia l. Pseudohyperkalemia A Cellular efflux; thrombocytosis, erythrocytosis, leukocytosis, in vitro hemolysis B.
Drugs: nonsteroidal ... anti-inflammatory drugs ... Drug-associated: ... #Differential #Diagnosis ... High #Potassium #Classification
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Heart, lung, and kidney ... erythematosus [SLE ... ) • Sepsis • Drug-induced ... with leukopenia, anemia ... Activation #Syndrome #Diagnosis
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
again we might see ... circulation If drugs ... 30mmHg) - Severe anemia ... Alcohol • Type B2: Drugs ... #typea #typeb #classification
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