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diagnosis management differential criticalcare overview candidemia cell fever fungemia hematology histiocytosis immunecompromised immunocompromised langerhans lch sepsis septic septicshock
SEPSIS AND SEPTIC SHOCK DEFINITION AND PATHOPHYSIOLOGY • Sepsis: Life-threatening organ dysfunction due to a dysregulated host
• 49 million cases ... COMMON CAUSES + ... , fungi (e.g., Candida ... all suspected cases ... • Start broad-spectrum
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death -> end-organ dysfunction ... O2 delivery • MI ... #Classification ... #differential #causes ... #classification
Shock Overview A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
death -> end-organ dysfunction ... O2 delivery • MI ... #Classification ... #differential #causes ... #classification
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Bacteremia/Septic Shock ... Aspergillus • Candida ... or Neutrophil Dysfunction ... #Causes #Hematology
Invasive Fungal Infection (IFI) Invasive fungal infections are severe infections in which fungal pathogens invade normally sterile
Common Pathogens Candida ... (most frequent cause ... stay and broad-spectrum ... include fever, organ dysfunction ... Imaging studies (CT, MRI
Langerhans Cell Histiocytosis (LCH) Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
various tissues, leading ... populations) CLINICAL SPECTRUM ... • Endocrine Dysfunction ... X-rays, CT, or MRI ... PET-CT / MRI: Staging
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