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hepatology differential liver injury transaminitis chemistry laboratory rheumatology alkphos arthritis bilirubin causes classification dili disease druginduced hepatocellular interpretation liverenzymes metabolism
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Transaminase Levels ... By AST:ALT Ratio ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
- Differential Diagnosis ... Algorithm Severe ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
- Differential Diagnosis ... • Infections: Hepatitis ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Hepatocellular Level ... normal AST/ALT AST ... liver #chemistry #diagnosis ... transaminitis #LFTs
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
• Increased levels ... Laboratory #Metabolism #ASTALT ... AlkPhos #Bilirubin #Hepatology ... Pathophysiology #Diagnosis ... #LFTs
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... Algorithm DILI ... drugs, OTC (record start ... Liver #Injury #Diagnosis ... #Algorithm #hepatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
• Hepatitis B ... function tests (LFTs ... (to support a diagnosis ... arthritis) • Hepatitis ... laboratory #workup #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... be abnormal AST ... #differential #diagnosis ... #algorithm #hepatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... lesions-interstitial keratitis ... Tests: • CBC • LFT ... Complement (Low levels ... #rheumatology #
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