135 results
Idiopathic Thrombocytopenic Purpura 
Clinical:
 • Gingival 
 • Menorrhagia 
 • GI bleeding 
 • Intracranial
children) • Platelets ... extremely low platelet ... immunoglobulin • Splenectomy
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Differential Diagnosis Platelet ... trauma) • Post-splenectomy ... Diagnosis #causes #Platelets
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... Asplenia/post-splenectomy ... Thrombocytosis #Platelets
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... • Absence of platelet
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... ristocetin • Normal platelet ... count and platelet ... • Platelet flow ... Usually normal platelet
Post-splenectomy blood smear demonstrating Howell-Jolly bodies and target cells.

#Clinical #Pathology #BloodSmear #HowellJollyBodies #TargetCells #Splenectomy #Asplenic
Post-splenectomy ... #TargetCells #Splenectomy
Recommended Vaccinations for Asplenic Patients - Before and After Splenectomy

#Management #Asplenic #Asplenia #Vaccinations #PrimaryCare #Vaccines #Splenectomy
Before and After Splenectomy ... PrimaryCare #Vaccines #Splenectomy
Blood Product Components, Contents, Volume and Shelf Life

Whole blood (autologous or directed donations) - RBC and
WBC and platelets ... Hct 60% Platelet ... concentrate - Platelets ... Hct < .005) Platelet ... pheresis - Platelets
Thromboelastography (TEG) based therapy and Management

If r time prolonged -> FFP
If MA low -> plts/cryoprecipitate (if
cryoprecipitate If platelets ... < 50 - > platelet
Thromboelastography (TEG) Based Management
 - If R time prolonged -> FFP 
 - If MA low
cryoprecipitate - If platelets ... < 50 -> platelet