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differential causes management hematology workup nephrology ddxof evaluation peds em cardiology pulmonary endocrinology pediatrics dermatology neurology im treatment gastroenterology obgyn
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated Platelet ... - Differential Diagnosis ... Algorithm Peripheral ... Asplenia/post-splenectomy ... #Algorithm #hematology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
- Differential Diagnosis ... Platelet Count ... trauma) • Post-splenectomy ... #Differential #Diagnosis ... #causes #Platelets
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
children) • Platelets ... extremely low platelet ... immunoglobulin • Splenectomy ... Thrombocytopenia #Diagnosis
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... #differential #diagnosis
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... ristocetin • Normal platelet ... count and platelet ... • Platelet flow ... #differential #diagnosis
Thrombocytopenia - Differential Diagnosis Algorithm Decreased production: • Bone marrow suppression • Bone marrow failure • Bone
- Differential Diagnosis ... Algorithm Decreased ... #Differential #Diagnosis ... #Algorithm #hematology ... #platelets
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Algorithm Spurious ... Other: • Post-splenectomy ... #Differential #Diagnosis ... #Algorithm #Causes
Thromboelastography (TEG) based therapy and Management If r time prolonged -> FFP If MA low -> plts/cryoprecipitate (if
cryoprecipitate If platelets ... < 50 - > platelet ... TEG #Management #Diagnosis
Approach to suspected Heparin-Induced Thrombocytopenia (HIT) • Suspected HIT Algorithm • "4 T's" clinical probability score:
Suspected HIT Algorithm ... Thrombocytopenia (platelet ... Timing of onset of platelet ... HIT #hematology #diagnosis ... #4Ts #algorithm
Thromboelastography (TEG) Based Management - If R time prolonged -> FFP - If MA low
cryoprecipitate - If platelets ... < 50 -> platelet ... Management #treatment #diagnosis
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