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management hematology differential antinxp2 antinxp2dm apml arterial cardiology dermatomyositis differentiation ecg electrocardiogram elevation embolism hemophagocytic hlh leukostasis lymphohistiocytosis lysis oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... unless worrisome EKG ... #TLS #diagnosis ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... : HLH signs and ... • Infection should ... antibiotic therapy should ... management #treatment #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Prednisone 5mg/kg ... Differentiation #Syndrome ... #management #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... • Nephrotic Syndrome ... antibodies (APLS should ... Venous #Arterial #pathophysiology ... #hematology #differential
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
anterior chest wall, parts ... antiinflammatory properties e.g ... #Rheumatology # ... diagnosis #management ... #Dermatology
Causes of ST Segment Elevation - Differential Diagnosis Framework STEMI: • Upsloping convex STE: "Pardee's sign" +
- Differential Diagnosis ... STE: "Pardee's sign ... segments and T waves should ... (Eiffel Tower sign ... #ekg #electrocardiogram
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... , and back and shoulders ... (in a shawl sign ... #management #rheumatology ... #dermatology
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