47 results
Signaling Mechanism of PD-1 and PD-L1 and Inhibition of PD-1 Signaling in Microsatellite-Instability–High Cancers. MHC1 denotes
Microsatellite-Instability–High ... histocompatibility complex 1 #Pathophysiology ... MicrosatelliteInstability #NEJM
Stress Fracture: Pathogenesis and clinical findings
Abnormal biomechanics, Repetitive impact activities
=> Repetitive subthreshold mechanical loading
=> Bone strain
=>
Pathogenesis and clinical ... micro-damage exceeds ability ... #orthopedics #pathophysiology
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
Pathogenesis and Clinical ... S1 => Weakened stability ... MSK #diagnosis #pathophysiology
Herpes Zoster Mandibularis - The lesions were scattered along the area that is innervated by the
#Clinical #Photo ... Mandibularis #Rash #NEJM
A necrotic ulceration was observed on the right side of the tongue. Cervicofacial computed tomography, performed
giant-cell arteritis #clinical ... #photo #lingual ... Arteritis #tongue #NEJM
Purple Urine Bag Syndrome
Chronic, indwelling catheter + bacteriuria (Providencia, Klebsiella, E.coli*) + alkaline urine
Tryptophan → Indoxyl
Syndrome #PUBS #pathophysiology ... #clinical #photo
Femoral Head Fracture: Pathogenesis and clinical findings
 • Posterior hip dislocation -> Impaction force from femoral
Pathogenesis and clinical ... Complications: • Inability ... msk #diagnosis #pathophysiology
Macroglossia in Light-Chain Amyloidosis- Physical examination revealed macroglossia, with indentations from the teeth (Panel A)...A biopsy
treatment are critical ... #amyloidosis #clinical ... #photo #AL #lightchain ... #NEJM
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... presentation - Clinical ... - hemodynamic instability
Dirofilaria repens- Patient had first noted a nodule below her left eye (Panel A). Five days
Dirofilaria #repens #clinical ... #photo #NEJM #parasite